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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
11.21
Human Site:
S391
Identified Species:
16.44
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S391
T
A
N
S
S
K
P
S
N
C
Q
N
K
E
S
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S391
T
A
N
S
S
K
P
S
N
C
Q
N
K
E
S
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
R460
P
W
V
Q
V
H
S
R
R
V
L
P
P
C
A
Dog
Lupus familis
XP_853397
405
45606
S392
M
A
N
S
S
K
P
S
S
S
Q
K
N
K
D
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
P382
K
A
N
S
S
K
P
P
T
G
H
T
S
K
E
Rat
Rattus norvegicus
P59241
397
44856
P384
K
A
N
S
S
K
P
P
T
G
H
N
S
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
S292
N
S
S
K
A
P
N
S
L
K
S
Q
E
S
T
Chicken
Gallus gallus
XP_425725
409
46456
V391
H
R
L
P
L
K
D
V
L
V
H
P
W
I
T
Frog
Xenopus laevis
Q91819
408
46443
P397
I
V
K
N
S
Q
Q
P
K
K
K
D
E
P
L
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
R309
W
V
K
A
N
S
R
R
V
L
P
P
V
C
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
Q317
A
E
R
E
L
Q
L
Q
K
R
E
R
G
K
E
Honey Bee
Apis mellifera
XP_395732
327
37711
I316
D
V
L
R
H
P
W
I
V
Q
N
R
T
T
E
Nematode Worm
Caenorhab. elegans
O01427
305
34731
Q294
K
I
R
A
E
K
Q
Q
K
I
E
K
E
A
S
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
S267
E
N
S
K
K
K
P
S
S
S
S
T
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
V271
L
L
E
H
P
W
I
V
Q
N
A
D
P
S
G
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
L356
V
K
M
H
P
W
I
L
R
N
K
P
F
W
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
0
53.3
N.A.
40
46.6
N.A.
6.6
6.6
6.6
6.6
N.A.
0
0
13.3
26.6
P-Site Similarity:
100
100
6.6
66.6
N.A.
46.6
53.3
N.A.
40
13.3
40
20
N.A.
20
0
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
32
0
13
7
0
0
0
0
0
7
0
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
13
0
0
0
13
0
% C
% Asp:
7
0
0
0
0
0
7
0
0
0
0
13
0
0
7
% D
% Glu:
7
7
7
7
7
0
0
0
0
0
13
0
19
13
32
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
13
0
0
7
0
7
% G
% His:
7
0
0
13
7
7
0
0
0
0
19
0
0
0
0
% H
% Ile:
7
7
0
0
0
0
13
7
0
7
0
0
0
7
0
% I
% Lys:
19
7
13
13
7
50
0
0
19
13
13
13
13
25
0
% K
% Leu:
7
7
13
0
13
0
7
7
13
7
7
0
0
0
7
% L
% Met:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
32
7
7
0
7
0
13
13
7
19
7
0
0
% N
% Pro:
7
0
0
7
13
13
38
19
0
0
7
25
13
7
0
% P
% Gln:
0
0
0
7
0
13
13
13
7
7
19
7
0
0
0
% Q
% Arg:
0
7
13
7
0
0
7
13
13
7
0
13
0
0
0
% R
% Ser:
0
7
13
32
38
7
7
32
13
13
13
0
19
19
32
% S
% Thr:
13
0
0
0
0
0
0
0
13
0
0
13
7
7
13
% T
% Val:
7
19
7
0
7
0
0
13
13
13
0
0
7
0
0
% V
% Trp:
7
7
0
0
0
13
7
0
0
0
0
0
7
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _